Premarin is a combination of estrogen hormones. The main target of it is to avoid menopause symptoms. These symptoms are dryness of vagina, irritation, hot flashes, burning and others. Premarin fills the lack of estrogen in the organism. It may also be useful in other cases, which are not described here. Estrogen is very important hormone in the body. If there is not enough estrogen in your body it can lead to many health problems. You may use this medicine alone or in complex with insulin or others drugs. But it's strongly recommended to not use it with prescription and nonprescription drugs, dietary medicine, herbal drugs. If you have an allergy to Premarin or to some components it consists of don't use it. If you have an allergy to some drugs related to Premarin you should also avoid using of it. You should be careful in using it if you have an abnormal mammogram, high cholesterol, blood circulation problems and others. It's forbidden for using in case of pregnancy or if you are going to be pregnant.You should also ask your doctor if this medicine could be compound with other drugs you are taking. You should have consultancy with your doctor before using to prevent Premarin negative effects.